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Data can fight drug resistance

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Flu season is once again here and many South Africans will be turning to their trusted dose of antibiotics to resolve the outbreak as effectively as possible.  Despite this ongoing routine, South Africa is facing a huge problem.

A study led by Julia Gasson of the Western Cape Department of Health has revealed that local clinics are ignoring the guidelines on prescribing those antibiotics, and formal procedures are followed only 45% of the time.

Another global study, by the Center for Disease Dynamics, Economics & Policy (CDDEP), Princeton University, ETH Zurich and the University of Antwerp, analysed human antibiotic consumption in 76 countries and found it has increased worldwide from 11.3 to 15.7 defined daily doses (DDDs) per 1,000 inhabitants per day between 2000 and 2015.

The results of these actions are far-reaching. Antibiotics have begun to lose their effectiveness and we are developing a resistance to them. And the problem is more complicated than we had first thought. In one case, it was found that antibiotic resistant patients with infections such as E. coli and Klebsiella pneumonia had contracted a specific gene that had its origins on Chinese pig farms.

A crucial step in combatting antibiotic resistance lies in technological evolution

As a solution, scientists are now looking towards the field of bacterial genomics to tackle the global issue of antibiotic resistance. Genomics refers to the branch of molecular biology concerned with the structure, function, evolution, and mapping of our genes. This process can provide clarity around resistance mechanisms and even the evolution of various strains of disease. Today the process of genomics has also  become highly automated, which has been greatly accelerated through a combination of parallel processing and the advancement in data management processes.

Due these advancements, we are now entering a world of personalised medicine, whereby individual patients can be sequenced and comparative genomic analysis can provide vital information around the progression of resistant strains of disease. Within this context, technology plays a pivotal role in allowing bioinformaticians to work with and transfer data to clinicians in an efficient and timely manner.

NetApp is assisting to achieve this through our ONTAP Cloud storage software, which allows for the protection of genomic data whilst adding the flexibility to simplify the use of public cloud. We are currently seeing this process in action through our work with PetaGene – a team which originated from Cambridge University PHDs who required a novel approach to the problem of storing data associated genomics. Additionally, we are deploying the new and improved NetApp StorageGRID which now automates tamper proof retention of critical personal data. With an increased focus on data analytics, StorageGRID customers retain and manage an unlimited amount of rich media, which is particularly useful for the field of genomics.

The key benefits of applying technology to scientific research

Unlike generic data reduction techniques, there are a few key benefits of applying the process of data management to the pursuit of tackling antibiotic resistance:

o   Increased collaborative efficiency, with smaller more portable files transferable over the NetApp data fabric

o   Use less storage capacity and lower costs

o   Leverage the flexibility of the cloud. With the NetApp data fabric, files can be seamlessly and securely moved to and from the cloud

o   Maintain interoperability with existing workflows and formats

The field of genomics, underpinned by efficient data management, is the way forward in combatting the global issue of antibiotic resistance. This of course needs to be coupled with the necessary behavioural changes where prescription guidelines are followed to the tee. Within South Africa, a country marred by drug resistant infectious diseases ranging from HIV through to malaria, the need to simplify collaboration in genomics with improved data management has never been more crucial.

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Notre Dame, Scoop Makhathini, GoT, top week in search

From fire disaster to social media disaster, the top Google searches this week covered a wide gamut of themes.

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Paris and the whole world looked on in shock as the 856-year-old medieval Catholic cathedral crumbled into ash. The tragic infernal destruction of this tourist attraction of historical and religious significance led South Africans to generate more than 200 000 search queries for “Notre Dame Cathedral” on Monday. Authorities are investigating the cause of the fire that razed the architectural icon.

In other top trending searches on Google this week, radio presenter Siyabonga Ngwekazi, AKA Scoop Makhathini, went viral when it appeared he had taken to Twitter to expose his girlfriend, Akhona Carpede, for cheating on him. Scoop has since come out to say that he was not responsible for the bitter rant and that his account was hacked. “Scoop Makhathini” generated more than 20 000 search queries on Wednesday.

Fans generated more than 20 000 search queries for “Sam Smith” on Tuesday ahead of the the British superstar’s Cape Town performance at the Grand West Casino. Smith ended up cutting his performance short that night due to vocal strain.

Local Game of Thrones superfans were beside themselves on Sunday, searching the internet high and low for the first episode of the American fantasy drama’s eighth season. “Game of Thrones, season 8, episode 1” generated more than 100 000 queries on Google Search on the weekend.

As the festivities kicked off in California with headliners such as Childish Gambino and Ariana Grande, South Africans generated more than 2 000 search queries for “Coachella” on Saturday.

South Africans generated more than 5 000 search queries for “Wendy Williams” on Friday  as it emerged that the American talk show host had filed for divorce from her husband Kevin Hunter after 21 years of marriage. Hunter has long been rumored to have been cheating on Williams, which reportedly finally led to the divorce.

Search trends information is gleaned from data collated by Google based on what South Africans have been searching for and asking Google. Google processes more than 40 000 search queries every second. This translates to more than a billion searches per day and 1.2 trillion searches per year worldwide. Live Google search trends data is available at https://www.google.co.za/trends/hottrends#pn=p40

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5G smartphones to hit 5M sales in 2019

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According to the latest research from Strategy Analytics, global smartphone shipments will reach a modest 5 million units in 2019. Early 5G smartphone models will be expensive and available in limited volumes. Samsung, LG and Huawei will be the early 5G smartphone leaders this year, followed by Apple next year.

Ken Hyers, Director at Strategy Analytics, said, “We forecast global 5G smartphone shipments will reach a modest 5 million units in 2019. Less than 1 percent of all smartphones shipped worldwide will be 5G-enabled this year. Global 5G smartphone shipments are tiny for now, due to expensive device pricing, component bottlenecks, and restricted availability of active 5G networks.”

Ville Petteri-Ukonaho, senior analyst at Strategy Analytics, added, “Samsung will be the early 5G smartphone leader in the first half of 2019, due to initial launches across South Korea and the United States. We predict LG, Huawei, Xiaomi, Motorola and others will follow later in the year, followed by Apple iPhone with its first 5G model during the second half of 2020. The iPhone looks set to be at least a year behind Samsung in the 5G smartphone race and Apple must be careful not to fall too far behind.”

Neil Mawston, executive director at Strategy Analytics, added, “The short-term outlook for 5G smartphones is weak, but the long-term opportunity remains huge. We forecast 1 billion 5G smartphones to ship worldwide per year by 2025. The introduction of 5G networks, by carriers like Verizon or China Mobile, opens up high-speed, ultra-low-latency services such as 8K video, streaming games, and augmented reality for business. The next big question for the mobile industry is how much extra consumers are really willing to pay, if anything, for those emerging 5G smartphones and services.”

Strategy Analytics provides a snapshot analyses for the outlook for 5G smartphone market in this Insight report: 5G Smartphones : From Zero to a Billion

Strategy Analytics provides a deep-dive into the air-interface technologies that will power phones through 2024 across 88 countries here: Global Handset Sales Forecast by 88 Countries and 19 Technologies : 2003 to 2024

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